aureus bloodstream infections and also has higher mortality rates 3. MRSA is widespread, accounting for 37% of S. This is particularly notable for the Gram-positive bacteria Staphylococcus aureus where the rise of methicillin resistance (MRSA) has led to an increased reliance on last-resort antibiotics. However, their durability is hampered by the emergence of bacterial resistance 1, 2.
Thus, we propose antibiotic-chemoattractants as an alternate approach for antibiotic development.Īntibiotics have become a cornerstone of modern medicine, allowing the prevention and treatment of once deadly infections.
Furthermore, optimizing the formyl peptide sequence can enhance neutrophil activity through differential activation of formyl peptide receptors. We use a combination of in vitro assays, cellular assays, infection-on-a-chip and in vivo mouse models to show that the compounds improve the recruitment, engulfment and killing of S. The compounds, which we term ‘antibiotic-chemoattractants’, consist of a formylated peptide (known to act as chemoattractant for neutrophil recruitment) that is covalently linked to the antibiotic vancomycin (known to bind to the bacterial cell wall). Here, we present a class of antibacterial peptides with potential to act both as antibiotics and as neutrophil chemoattractants. The pathogen Staphylococcus aureus can readily develop antibiotic resistance and evade the human immune system, which is associated with reduced levels of neutrophil recruitment. Nature Communications volume 12, Article number: 6157 ( 2021) Antibiotic-chemoattractants enhance neutrophil clearance of Staphylococcus aureus
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